The greater your skill, the less good luck you need
Agree with others that the best part for me is by far the draft.
When drafting, I believe the following is true:
1) Zig when others zag
2) The value of players on your draft board changes significantly based on the players you have already drafted. I try to balance my early picks to give me the most flexibility later on (although I don't always hold to that - if everyone picks an RB in the first two rounds I will draft other positions first, likely WR)
3) I like having a strong RB1, but strengthening other positions before picking my RB2 tends to work better for me than picking two strong RBs to start a draft.
4) In PPR, 3rd down backs are typically undervalued and make fine RB2s.
5) A lot of people still don't get the basic concept of VBD
6) My teams end up better when I don't "have" to have a guy. If there's a decent chance he makes it to the next round, I will pick someone else, even if I believe the person I am drafting is less valuable. Sure, sometimes you get burned but usually your team ends up being stronger.
7) If you're in multiple leagues, you have no realistic shot to win all of them because you are drafting different players. But I like to manage risk across my teams to give myself a good chance to win a good number of them. This means I can take the handcuff for a RB I have in league A in league B or C. This gives me leverage to take people at value and not reach for a player (see #6).
For after the draft, it's more valuable to spend your money early than late. Try to be patient with the younger guys you have on your team. If they are playing well but have limited opportunity, that opportunity will likely come later in the season. But players that are not doing well with their opportunity don't belong on your team. Unless they are playing through injury (think CJ Anderson and Michael Floyd last year).
Lastly, I play in a lot of leagues but I will never quit my two leagues played with friends because those are so much more fun.