Speaking of week one, there doesn't seem to be any matchups in which one team is clearly going to win (for example, no Indianapolis vs. Cleveland type matchups). But I suppose week one is always that way with all the questions on each and every team's potential.
MIN at NO
CLE at TB
MIA at BUF
CIN at NE
IND at HOU
DEN at JAC
ATL at PIT
OAK at TEN
CAR at NYG
DET at CHI
ARI at STL
GB at PHI
SF at SEA
DAL at WAS
BAL at NYJ
SD at KC
Tough choice if you play survivor pick'em, in my opinion.
I personally like Tampa at home against Cleveland as far as a non-top defense in Week One.