I took him as WR14 in my 14 team, 0.5PPR, no return points league.
Last season, Hill score 10.7ppg in our scoring system, and he played only 40% of the snaps. With Maclin's departure, and Hill's promotion to starter, I expect 80% of snaps on a per game basis. Last year he had a high utilization rate (rushes+targets)/snaps or 25.5%, and I expect that to drop to around 20%. 10.7 x (80%/40%) x (20%/25.5%) comes out to 16.7 ppg, which would have put him in the top 3 in my league.
Looking under more of a microscope...
As a rookie, he played 16 games, but only started 1. His rushing stats were 24/267/3 and his receiving stats were 61/83 = 73% catch rate, 593 yards, 9.7 Y/R, 6 TDs.
He'll have more rushes and he'll have more targets: Hill only played 418 (40%) offensive snaps last season, and had a relatively high usage rate of 25.5% (rushes+targets)/snaps. Maclin has left and Hill is an undisputed starter. Given a healthy season, I'd expect a ridiculously hard floor of Hill playing 60% of the snaps, but it'll likely be closer to 80%+ of snaps. That said, his usage rate is likely to decrease from 25.5%, maybe to 20%. Those ranges results in estimates of 29-38 rushes and 99-132 targets.
He'll have better Y/R: Last year there were a ton of passes to Hill when he was behind the LOS, and he was ranked 113th in the league in Y/R. Given the departure of Maclin, Tyreek will be playing from more positions and running a higher percentage of intermediate and deep routes. I expect his Y/R to go up 2-3 yards. 12.5 Y/R would put him around 60th in the league, and it's not a crazy expectation to think he'd be in the same range as Jamison Crowder, Corey Coleman, or Jermaine Kearse in terms of Y/R. At the same time, with longer routes, we should expect his catch rate to drop, maybe to the 65% range.
It's likely he can't sustain 11y/a rushing, so let's consider the ranges from 6-9y/a.
He had an insane touchdown rate last season, likely unsustainable. But at 50-100% more snaps this year, I'll keep his TDs at 8-12.
Using those numbers, my ranges are 29/174 - 38/342 rushes/yards, and 64/804 - 86/1072, and 8-12 TDs. The midpoint estimates (70% of snaps, 20% utilization rate, 65% catch rate, 7.5 YPC, 12.5 Y/R) feel reasonable, and result in 34 rushes for 251 yards, 75 receptions for 938 yards, and 10 TDs. That's a weekly rate of 13.5 fppg with my league rules, good for WR9 last season. Bumping to 80% of snaps, 9Y/C puts him at 14.9 fppg, on par with WR5 TY Hilton at 15.0fppg.
It wouldn't be surprising if Reid decided to use Hill out of the backfield more than he did last season. It wouldn't be surprising if Ware's injury and slightly less depth at the position resulted in more touches from the backfield.