If you mean from a points perspective, they're basically all tiered based on price so you'll earn based on what your company is spending. You can get info through the sites as to how they tier their hotels. I think a popular criticism of Hilton is that they expanded to something crazy like 10 tiers.
If you mean from a value perspective, similar to above...you'll want to stay in the most expensive one you're allowed. Some have different perks though. Residence Inn (Marriott) is a popular business travel hotel with that brand as they give you breakfast and sometimes "dinner" which is nice if you get a per diem you could pocket. I always liked Embassy Suites (Hilton) as the breakfast was pretty solid and they did open bar happy hours in many locations. That was a jackpot as a 22 year old traveling with many others around my age.