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Obesity and Ozempic and more (1 Viewer)

I say all that full well knowing that something could be really bad in the offing, but somehow for now the lizard is king. He does everything!

(I didn’t know this, but the drug is derived from a lizard’s internal secretion of fluid somewhere for some reason).

🦎

She’s a beautiful one indeed

 
I say all that full well knowing that something could be really bad in the offing, but somehow for now the lizard is king. He does everything!

(I didn’t know this, but the drug is derived from a lizard’s internal secretion of fluid somewhere for some reason).

🦎

She’s a beautiful one indeed

The cardiologists I trust the most about stuff like this seem to think that its ability to reduce inflammation is driving a lot of this. Inflammation leads to a lot of bad things, so keeping it down is likely to do a lot of good things.

Another study presented at the ESC showed that inflammation was a bigger factor than cholesterol for prediction of 30-year heart disease risk in women. 70% greater risk for women in the top 20% of an inflammation biomarker vs women in the bottom 20%. LDL (“bad” cholesterol) and Lp(a) (an even worse cholesterol for which specific treatments will be available soon) had a difference of about 35% in the highest and lowest groups.

The researchers recommended that everyone be tested not only for LDL, but also for Lp(a) and CRP (the inflammation biomarker).
 
Maybe dumb Qs, but I'm having a hard time finding answers...

If I've dropped my BMI from 36.2 to 32.9 and ramped up activity levels to maybe 240 mins a week of moderate activity (over last 2-3 months) and I haven't been diagnosed with any sort of diabetes or etc already, do I get the benefit of a lower chance of getting diabetes or other weight-related diseases today? Is going in a good direction protection in and of itself? Or do you have to get all the way back down to healthy levels to get that benefit?
 
Maybe dumb Qs, but I'm having a hard time finding answers...

If I've dropped my BMI from 36.2 to 32.9 and ramped up activity levels to maybe 240 mins a week of moderate activity (over last 2-3 months) and I haven't been diagnosed with any sort of diabetes or etc already, do I get the benefit of a lower chance of getting diabetes or other weight-related diseases today? Is going in a good direction protection in and of itself? Or do you have to get all the way back down to healthy levels to get that benefit?
Not a doctor but a medical journalist. My sense is that it’s a sliding scale. You are already in a better position than you were before starting the drug, but the biggest benefits will come with greater degrees of weight loss.

Of note, at a conference I was at earlier this year, the panelists for the obesity session were asked if patients should be on GLP-1s (Ozempic, Wegovy, Mounjaro, Zepbound, etc) for life once put on them. They all said yes.
 
Just sharing my son's experience so far with wegovy. 3 months in IIRC
Currently at 1.0 dose. Next will be 1.7.
Down 51 lbs
Feels like crap for about 1.5 - 2 days after dosing.
Seems like every new prescription he calls 2-4 pharmacies to find one with the drug in stock.
 
Just sharing my son's experience so far with wegovy. 3 months in IIRC
Currently at 1.0 dose. Next will be 1.7.
Down 51 lbs
Feels like crap for about 1.5 - 2 days after dosing.
Seems like every new prescription he calls 2-4 pharmacies to find one with the drug in stock.

The consensus is building to make it a half dose 2x a week at 1.0 and above. Seems to help
 
Just sharing my son's experience so far with wegovy. 3 months in IIRC
Currently at 1.0 dose. Next will be 1.7.
Down 51 lbs
Feels like crap for about 1.5 - 2 days after dosing.
Seems like every new prescription he calls 2-4 pharmacies to find one with the drug in stock.
Yeah, there’s a shortage because a bunch of people are taking it purely for moderate weight loss when that’s not what it’s for — it’s for people with or at high risk for other diseases who could reduce their chances for those if they lost a lot of weight. Novo Nordisk is beefing up their manufacturing, so hopefully the supply issues will be resolved eventually.
 
Just sharing my son's experience so far with wegovy. 3 months in IIRC
Currently at 1.0 dose. Next will be 1.7.
Down 51 lbs
Feels like crap for about 1.5 - 2 days after dosing.
Seems like every new prescription he calls 2-4 pharmacies to find one with the drug in stock.

The consensus is building to make it a half dose 2x a week at 1.0 and above. Seems to help
He'll be getting a new doctor. Current doc, only 1 at the practice, is leaving.
It will be interesting to see how this plays out.
 
Interesting article on the carnivore movement
Self-proclaimed carnivores eat mostly four ingredients: beef, bacon, butter and eggs. (Some incorporate other raw dairy products, selected fruits such as blueberries and seafood into their regimens.) Influencers share recipes for delicacies such as “beef lattes” (coffee, butter, beef protein, colostrum, cinnamon) and snack on “pup patties” from In-N-Out’s secret menu (unseasoned beef, so called because you can safely give it to your dog).

According to its fans, the benefits of the diet range from rapid weight loss to the healing of long-term chronic conditions including depression, polycystic ovary syndrome, acne, eczema, diabetes and psoriasis.

According to almost everyone else – including the registered nutritionists and doctors trying to treat people who have tried the diet for prolonged periods – a diet of only meat with no vegetables or grains is, at best, a form of disordered eating, and at worst incredibly damaging for its adherents, particularly in the long term.
 
Interesting article on the carnivore movement
Self-proclaimed carnivores eat mostly four ingredients: beef, bacon, butter and eggs. (Some incorporate other raw dairy products, selected fruits such as blueberries and seafood into their regimens.) Influencers share recipes for delicacies such as “beef lattes” (coffee, butter, beef protein, colostrum, cinnamon) and snack on “pup patties” from In-N-Out’s secret menu (unseasoned beef, so called because you can safely give it to your dog).

According to its fans, the benefits of the diet range from rapid weight loss to the healing of long-term chronic conditions including depression, polycystic ovary syndrome, acne, eczema, diabetes and psoriasis.

According to almost everyone else – including the registered nutritionists and doctors trying to treat people who have tried the diet for prolonged periods – a diet of only meat with no vegetables or grains is, at best, a form of disordered eating, and at worst incredibly damaging for its adherents, particularly in the long term.

Two things:
1. One thing I hope is that we analyze if and why some of these benefits occur.
2. Why are they only eating beef and bacon and not chicken, fish, other pork, etc?
 
Well it looks like I'm going to give Ozempic a try. I could stand to lose some weight but I'm not obese. Think I'm around 217. A little over 6 feet. All time high is 242 maybe 10 years ago and I've gotten down to 200 before through strict diet and exercise. Felt really good at that weight. Of course the recommendations for my height is somewhere around 180, which I haven't been since high school. So it isn't about weight loss per se but I'd welcome it, as it's getting harder to lose weight as I age. Diabetes is rampant in my family. Dad died due to complications, leg amputated, brother has had toes amputated, other brother had blood sugars over 800 when first tested, etc. (he has lost 75 pounds on another program and is doing great now). I'm not diabetic but technically pre. Been mostly in the 5.8 A1C range but has crept to 6. Most of you know I had a widowmaker 5 years ago after I got off a vigorous Peloton ride. My cardiologist is more concerned with blood sugars than anything else. Blood pressure, cholesterol, other numbers all great as are stress test and carotid artery tests. But you don't want diabetes on top of a previous heart condition. Metformin did nothing. Now on Jardiance. Getting a blood test soon. I went to my primary care doc for a physical and discussed it. He said let's try for Ozempic and see if your insurance will approve it. Well - I just got a notification from CVS that they did and it's ready for pick up. $25. Not bad. So I'll likely start this as soon as I return from Greece in two weeks. My friend had her A1C go from 6.5 to 5.6 after a few months on Ozempic. Will report back.
 
2 years ago to the day I was 272 lbs.
1 year ago after working out for a year I hit a major wall at 254 lbs.

Honestly I was in adequate shape at 254 lb no matter what the BMI charts say. I could play BBall for 2-3 hours a couple nights a week, played indoor soccer, jog a 5k, etc with no problem. Yes there was too much around the waist, but my fat percentage was average. And that's the number that matters IMO.

A year later .... started Oz in ~November 2023. As of March was at 232 lbs. I did not change my diet or routine. It stops the cravings. I simply eat far less. Never feel the need to stop for fast food or eat at night. Oz was a bit rough at the start from being tired. But it went away after 2 weeks. In April I went off it to see if I could keep the weight down. I am still at 232 lbs. I am now going to do monjauro to see if I can knock out more weight. Would love to be at 210 lbs. Which was my fighting weight playing college sports.

Also I am off all my blood pressure and cholesterol meds. Those problems went away within 2 months of taking Oz.

Just saying ... it helps those of us that aren't blessed with great fat genetics and/or have bad food habits, though I've helped the latter by making scrambled eggs and air frying raw shrimp my snacks. Oz was was the best medical decision I've made. Even better than being a guinea pig for lasik in the 90s.

Don't hesitate to give it a try and see if it helps you.

ETA ... I also fired my doctor 1.5 years ago because she did not want me to take it. Said she had patients that needed it more. Getting rid of her and going to telehealth really helped. Some of these old school docs following their charts and procedures from 2000 are part of the problem. If you get yourself fixed up, you no longer need to see them. Healthcare is a complete mess. Take it into your own hands.

Update now at 214 lbs. So down 58 lbs from my highest and about 40 from former normal. Down from a size 40 to 35.

Feel fantastic 95% of the day. I'd say the one thing I need to do now is lift weights. I've always been muscular and I'm losing it. this makes me sore after longer activities like walking a golf course, playing with kids at the beach, etc). It's not so much about the intensity, it's the duration. So be prepared to hit the weights as you lose pounds. I haven't done it enough and i feel it.
.
 
Do we know how it accomplished that? As with almost everything else it does, not really.

They’re going to find out something bad about this drug. I swear. Give ‘em enough time. Because right now it’s an aid to addiction, weight loss, dementia, COVID morbidity, and other things I’m probably forgetting.

I :love: my drug. Still hovering around 188 pounds or so. Maybe 190, up from 184 a few months ago. Still loving it.
Why are you taking it at that weight? Were you much heavier or have diabetes? I fluctuate between 183 and 189 I’m 5’10. Just curious
 

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