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*** OFFICIAL *** COVID-19 CoronaVirus Thread. Fresh epidemic fears as child pneumonia cases surge in Europe after China outbreak. NOW in USA (6 Viewers)
- Thread starter Big League Chew
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Terminalxylem
Footballguy
You’re gonna be sorely disappointed then, as there’s no end in sight. And between election celebrations and protests, there’s a good chance we’ll see a superspreader event or three in the next few weeks.
It’s gonna be really interesting to see how things change when Biden’s in charge, but he’s likely to start in a bad place.
Osaurus
Footballguy
KarmaPolice
Footballguy
I don't think a week goes by without someone at the store having to be out while getting tested for one reason or another. This time it was a manager who just had to go to some video game event and got news that the person he was with tested positive. Good timing for me to have to train him all last week and work with him about 10x more than I normally do. He got tested on Friday, so we should get results back. If it happens to be positive, that basically takes the store out for a bit as the GM and I will be out to get tested, as will the opening staff. Pretty sure that is what will have to happen anyway.
Terminalxylem
Footballguy
OK. My bad. I don’t recognize that poster, but there’re more than a smattering of Trumpian conspiracists who share that sentiment.
top dog
Footballguy
My son works at Walmart. A coworker he works closely with had her dad (who she lives with) test positive. He kind of freaked out as she called off on thursday sick. She is getting tested. My son is feeling fine and has no symptoms. I told him at this point if he had it, he would have exposed us as well. He hasnt seen the coworker since Wednesday. I think he (and us) will be fine, but I told him if he starts to have any symptoms, go get tested.
Stay safe everyone.
Stay safe everyone.
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Don Hutson
Footballguy
worrierking
Footballguy
Heart inflammation from COVID is less common than previously feared.
https://www.upi.com/Health_News/2020/11/04/Heart-inflammation-from-COVID-19-less-common-than-thought/4441604499783/
https://www.upi.com/Health_News/2020/11/04/Heart-inflammation-from-COVID-19-less-common-than-thought/4441604499783/
culdeus
Footballguy
In a sort of odd situation, my office actually reached out in a way they never have about plans for Thanksgiving and Christmas. Specifically asking if we would be travelling. Phrased in a very HR/Legal sort of way as to not make it a requirement to answer.
Highly unusual.
Highly unusual.
That one guy
Footballguy
Our local theater (playhouse) sent out flyer for new show starting in a little over a week. Not a single mention of covid, social distancing, limited capacity, safety requirements such as masks, nothing. I found that highly odd and went to their website, same, not the slightest mention of anything. I’m curious as to how it’ll be received and attended. The fam won’t be in attendance like normal
beer 30
Footballguy
It’s Nov 9th, I got into a discussion with someone last night that was blasting Biden because he’s pushed a national mask mandate because, “a national mandate should come through the legislative branch of our government and not by executive order.” People still fighting wearing a mask as we set records everyday for new cases. Weather hasn’t even gotten bad yet and we are at 126,000 new cases a day. We’ll be double that by January at this rate.
https://www.nytimes.com/2020/11/09/health/covid-vaccine-pfizer.html
Pfizer vaccine "more than 90% effective" in phase 3 trial. Like Moderna's, this one is based on mRNA and is not a killed or weakened version of the virus. Instead it builds a genetic doppelganger that the body then learns to fight off.
Pfizer vaccine "more than 90% effective" in phase 3 trial. Like Moderna's, this one is based on mRNA and is not a killed or weakened version of the virus. Instead it builds a genetic doppelganger that the body then learns to fight off.
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worrierking
Footballguy
IvanKaramazov
Footballguy
CR69
Footballguy
So holy crap and amazing news but is this anything to be concerned about?
"The shot relies on messenger RNA technology never before used in an approved medicine. Using mRNA, which essentially teaches the body’s cells to become vaccine factories, allowed it to be developed much faster than a traditional vaccine."
https://www.bloomberg.com/news/articles/2020-11-09/pfizer-s-covid-vaccine-prevents-90-of-infections-in-large-study
"The shot relies on messenger RNA technology never before used in an approved medicine. Using mRNA, which essentially teaches the body’s cells to become vaccine factories, allowed it to be developed much faster than a traditional vaccine."
https://www.bloomberg.com/news/articles/2020-11-09/pfizer-s-covid-vaccine-prevents-90-of-infections-in-large-study
themeanmachine
Footballguy
As vaccines start to be produced in large quantities (which will take several months), I wonder in what cases they will be required. Will companies require employees to get vaccinated before going back to the office? Countries require proof of vaccination before traveling? Colleges require vaccination before students come back to campus in Fall 2021?
A lot of people would rather take their chances with corona rather than technology never used before in a medicine
CR69
Footballguy
worrierking
Footballguy
Personally, I believe it is my patriotic duty to take the vaccine as soon as it is feasible. Defeating the virus is the most important thing we can do for our society. My wife did not want me to volunteer for the trials, but I am taking any approved vaccine.
culdeus
Footballguy
In the coming months you will hear the phrase, the biggest risk is it doesn't work and people go back to their normal lives.
The odds that this catches and reacts to all strains is not 100%. The odds that it somehow causes harm is very likely 0.
Another thing you'll likely hear is that you take in slightly different RNA sequenced bacteria every time someone farts near you. In fact odds are when you bang a chick even once it's altogether likely you pick up her unique poop rna bacteria and spread it by farting indefinitely.
I'd rather take a vaccine that teaches my immune system to recognize the virus by using a snippet of it's DNA instead of taking one made in a rush using a weakened form of the virus. Who knows what the side effects are a year out or if they didn't weaken it enough. Who knows if they did a good enough job in the long run when we're doing this at 'warp speed'.
Instead give me a thing that if something goes wrong... It can't hurt me. With a few hundred letters of mRNA and one protein, if it doesn't work it doesn't seem to make anything dangerous.
The reason it's never been done before is it's just such a new idea that we haven't had any thing to use it against yet.
beer 30
Footballguy
Over the months this thread has taken twists and turns as all long running threads do. They have been entertaining and disappointing, sometimes all in the same post.
That said, while I've been following since early on, I've never subscribed to the thread for updates...until now. Finally getting interesting in here
Cold Dead Hands
Footballguy
MTskibum
Footballguy
I thought 2020 would be defeated in early January. Learn something new every day.
Redwes25
Footballguy
They do not as that is considered unethical. They give a lot of people the vaccine and another large group a placebo. See if the placebo people are getting sick compared to the vaccine group.
I think they signed up 43,000 people who are moderate-to-high risk (not just people who work from home and aren't out exposed that much) then just see how many got sick.
Capella
Footballguy
Hmmmmm. How does that determine how effective it is then? I get the placebo comparison, but what if the people in the vaccine arm are just more careful, stay at home, wear masks, etc? Obviously these people know more than me and I’m just some dumb guy, just trying to understand.
Redwes25
Footballguy
I am not an expert on this but they give it to a lot of people and some will be risk takers and others won't but those will be spread between Placebo and real Vaccine. I understand on Pfizer trial they gave it to like 40k people. Of the people that got sick so far only 10% have had vaccine and other 90% got Placebo. That is where the 90% number comes from.
I think they intentionally sign up people who are not just staying at home all the time, but are in public-facing positions and therefore more exposed. Signing up 40,000+ of them gives a solid sample I think.
Cold Dead Hands
Footballguy
It is a fairly big study, trial wise, for a vaccine this early in the process. It is good news,
while statistically significant, the effectiveness could, and probably will, shift when large populations are vaccinated. Hopefully it is a minor fluctuation, but early expectations were 60% efficacy at best, so even a shift 10 points lower would be a huge success
Flash
Footballguy
culdeus
Footballguy
I don't think that's exactly how it works. They are saying of the people that got the vax vs not the not got it 90% more than the vax population did. They specifically outlined they need about 200ish more people to test positive to have what would otherwise be a 6 sigma level of confidence.
Jackstraw
Footballguy
That's why the large scale tests I assume. The variance in behavior evens out through sheer numbers.
If I toss a coin four times it might well go heads 75% of the time. If I toss it 400 times, chances are very close to a 50/50 ratio.
Redwes25
Footballguy
Think we are describing same thing - of people in the trial who got Covid only 10 percent were people who got vaccine. Other 90 percent got the placebo.
https://www.cnn.com/2020/11/09/health/pfizer-covid-19-vaccine-effective/index.html
culdeus
Footballguy
Right, I think the confusion is people think 10% of the vax population got it and 90% of the placebo got it, which isn't the case.
Dezbelief
Footballguy
That's how they tested the polio vaccine, some children died and some paralyzed when exposed to the virus after being given a placebo.
culdeus
Footballguy
ShamrockPride
Footballguy
Welp, just had a minor health scare this past weekend (which seems like everything should be fine going forward after getting checked out).
Just as a precautionary measure, and to make sure we explored all avenues to figure out what may have been going on, they decided to test me for it. Just got results back today that it came back negative, but whew.....that test sucked lol. Glad I won't need to do anymore. Pretty sure as they were nearing the back of my nasal passage I was screaming like a girl for a couple seconds lol.
Just as a precautionary measure, and to make sure we explored all avenues to figure out what may have been going on, they decided to test me for it. Just got results back today that it came back negative, but whew.....that test sucked lol. Glad I won't need to do anymore. Pretty sure as they were nearing the back of my nasal passage I was screaming like a girl for a couple seconds lol.
fred_1_15301
Footballguy
Assuming it's a randomized trial (and large enough), the 2 groups (vaccine and placebo) should be theoretically balanced on all baseline characteristics. The beauty of randomized trials.
Found it in the Pfizer Clinical Protocol (PDF) for this study. For Phase 2 and Phase 3 (these results are now from Phase 3), they specifically included only:
They excluded: anyone with a medical or psychiatric condition that would leave them unlikely to participate for the full length of the study, anyone with an immunodeficiency virus (HIV, Hep B, Hep C), anyone with a history of adverse reactions to vaccines, anyone who's taken any other medication that is intended to be preventative toward covid-19, anyone who's already had covid-19, anyone with a co-morbidity putting them at elevated high-risk for severe covid complications if they did catch it, anyone immunocompromised, anyone with a bleeding disorder or condition that would make injections problematic, anyone pregnant or breastfeeding, anyone who's taken any other coronavirus vaccine, anyone on immunosuppressive therapy, anyone who needs blood transfusions regularly, anyone who's failed to complete a study as a test subject before, and a few other restrictions.
Peak
Footballguy
Finally out of my Covid Isolation orders from the Health Dept. My family is also done with their 14 day quarantine. This is the first day the kids and wife get to go back to school. Curious to see how long this will lasts, as my kids school has been rising in illness numbers over the last month. They're already going to use Remote Learning one day a week, while going in person the other 4 days.
Personally, still can't taste or smell, and small frequent headaches. Other than that, I'm not too bad. I get a dry cough at night for some reason, but it's gone by the morning. Everyone else is healthy in the home, so that's good. It was definitely a miserable 10 days.
Personally, still can't taste or smell, and small frequent headaches. Other than that, I'm not too bad. I get a dry cough at night for some reason, but it's gone by the morning. Everyone else is healthy in the home, so that's good. It was definitely a miserable 10 days.
IvanKaramazov
Footballguy
One of our student workers tested positive last week, so everybody in my office -- me included -- are now in sort of a soft quarantine until next Wednesday. This is definitely overkill in my case. I have a private office, I'm not 100% sure that I even saw our student once last week, and even if I did I'm positive it was "fleeting contact" that wouldn't have amounted to more than a few seconds of walking in/out of the suite. But regardless, I'm on WFH for a little while.
Our office is also planning to go to a rotating schedule where half of us around each week and the other half are at home. This is part of an effort to "de-densify" (hate that term) all of our campus offices wherever possible. Not sure how long that will last, but my guess is that it will go all through the spring semester. I doubt any vaccine will be widely available to non-essential scrubs like me before then.
Until around August or so, I didn't personally know a single person who had tested positive for covid. Now all the sudden I know a dozen or so people who have contracted it. It still seems insane to me that we shut everything down back in March when this was no big deal in my area (the Dakotas), but now we're going to just keep on trucking despite having the worst outbreak in the US at the moment, but hey YOLO I guess.
Our office is also planning to go to a rotating schedule where half of us around each week and the other half are at home. This is part of an effort to "de-densify" (hate that term) all of our campus offices wherever possible. Not sure how long that will last, but my guess is that it will go all through the spring semester. I doubt any vaccine will be widely available to non-essential scrubs like me before then.
Until around August or so, I didn't personally know a single person who had tested positive for covid. Now all the sudden I know a dozen or so people who have contracted it. It still seems insane to me that we shut everything down back in March when this was no big deal in my area (the Dakotas), but now we're going to just keep on trucking despite having the worst outbreak in the US at the moment, but hey YOLO I guess.
The Commish
Footballguy
I know a large part of it is an analysis to see what kind of antibodies the individual creates. I'm sure there are other parts to it, but that's a big one. I thought the need for placebo group was there to try and weed out the psychological variables. I could be mistaken.
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