Doug B
Footballguy
... touching on nasal vaccines, etc. (not much good news on that front, as expected)
Must be a blind spot on my part -- I had thought there was legitimate hope with the nasal vaccines. Still, I haven't kept up lately -- It will be a nice catch-up to read Topol's summary.
EDIT: Oh -- I thought you meant that Topol's article said nasal vaccines were at a dead end and weren't going to happen. Upon reading your link, quite the opposite. Quoting Topol's article below:
Nasal Vaccines
We have to get nasal vaccines into high gear to markedly reduce infections and spread. This week I did a Ground Truths podcast with Shane Crotty, one of the leading US immunologist and virologists, on his landmark paper in Nature. By doing nasal and nasopharyngeal swabs every month in 100 participants throughout a year of the pandemic, his team identified the determinants of nasal (mucosal) immunity, which we aren’t going to get from shots. He, like me and many others, including Akiko Iwasaki, remain quite optimistic we’ll get a successful nasal vaccine. That was reinforced by a report from the Washington University group that developed a nasal vaccine and licensed it to India (where it is approved and used). In hamsters, a widely used and accepted experimental SARS-CoV-2model, their nasal vaccine blocked spread. Besides blocking transmission, it reduced infectious virus titers ~100-fold and 100,000-fold in the upper and lower respiratory tract, respectively, of the primary contact following SARS-CoV-2 exposure. That did not occur with mRNA shots.
The investment of the US for Project NextGen has been minimal to develop nasal vaccines with only 2 programs supported and it’s moving quite slowly. I don’t understand why the Washington University nasal vaccine is not being assessed in the US, including regulatory guidance and oversight. And there are many other candidates from academic labs at Mt. Sinai, Emory ,Yale and others. What a missed opportunity.
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