I've been bullish severe the whole time... M2M, especially on such a small sample size was always going to be tough. I think we've demonstrating safety, which is good and certainly one hurdle out of the way when you calm down and look at the whole puzzle. In the severe since the key endpoint is death, there is no massaging statistical benefit, it's black and white. Maybe you could on some of the secondary endpoints, but if the drug shows it saves lives, and it's safe, it could be a good frontline treatment. This is and has been my bullish Covid stance for a while.
My bullishness on severe is simple, we know the MOA. Calming the cytokine storm by blocking CCR5, which should reduce inflammation. No short or long is going to talk me off of the science. If it succeeds there, then when a person tests positive, given the safety factor, it could be considered a good frontline drug. This gives it $50-$60 potential, but that is a stretch.