So this is my first time doing SF, but I'm joining a new league that is used to SF so that is why I'm trying to figure out what typically happens. Passing TDs are only 4 pts. I'm picking towards the middle of the round so I'm probably going to be missing the first big 3 QBs. Feels a little like no mans land.
Sorry brother, I'm all over the map here but I did put a lot of thought into the post below, if you can puzzle it together. But I'm tired and don't want to edit. Good luck.
If this is an experienced, and well balanced, scoring wise (4pts/pass TD is a good start), league then middle of the first round is actually a great spot for your first SF draft, IMO.
If you have a crack at Burrow, Lamar or, probably Fields & Herbert, you're okay at QB and don't have to risk waiting. I would absolutely move on one of them. In my league I could realistically expect two of those four, at least to be available in the early 2nd, but probably not past pick 16.
It's not obligatory in a good SF league to take two QBs in the first two rounds, but if you get a crack at two of the top 7 this year, I would strongly consider it. It will make the rest of your draft a little more difficult, mostly due to unfamiliarity but, I promise getting two of the top seven QBs doesn't suck in SF leagues.
Bottom line is there is still going to be plenty of talent available at your 2nd round pick. If you took the QB in the first you have until, probably the 5th, on the far end, to grab your QB2 but the later you go with your QB2, the earlier you will need to target your QB3.
You should still check if a QB is falling far below ADP in the 3rd & 4th. The Draft Dominator seems to have incorporated actual SF data in their ADP data, if you configure it properly, I strongly encourage you to use it.
It's a trade off because the sleeper you think every one missed on in the 5th may be a pumpkin. For me last year it was Jameis, but thankfully I moved on Goff in the 8th, which was season saving.
Sorry, a bit stream of consciousness here but back to the end of the 2nd round: Trevor Lawrence is a great value. But at that point I stop being QB desperate. There is probably value at other positions that are equivalent, or better than, Dak, Jones, DeShaun (bit of a spec option) & Cousins (who is better than most people think). If your going to take a big swing on a QB there I rank Jones>DeShaun and I struggle between Dak & Cousins after them.
If you were bold and passed on QB in the 1st & 2nd you need to take a zero QB mindset and plan to take 3 QBs, probably in rounds 4 (at the very latest), 5 & 6. Maybe you can wait to 7 for your last one but it's a huge risk your first year in this format.
TL/DR: Because of your unfamiliarity with this format I would almost certainly go QB with your first round picks. After that you have a lot more flexibility.
Next year when you know the league better you may even wait until the mid 2nd to target your first QB.