Agholor needs to have a big game. His match-up against Newman is the closest to a plus-match in this game.
I think Newman is a better player than Agholor. So while this be something the Eagles need, and maybe this is the closes't to a plus match up for your receivers, I don't think it is a plus match up. Newman played on 56% of the defensive snaps for the Vikings this year, so he is on the field a lot. He is 12th in total number of snaps for Vikings defenders on the year.
Mckenzie Alexander is the weakest corner the Vikings might play. He did not practice on Friday however and listed as questionable with a rib injury he has been dealing with for 3-4 weeks now (sort of seems like he should be healed by now to me, but maybe not). He has played 32% of the defensive snaps. Occasionally he has been in the line up over Newman, but most of the time he plays when the Vikings go with 4 corners.
If Alexander doesn't play the Vikings 4th corner would be Marcus Sherels or Trumane Brock.
Ertz against a linebacker may the Eagles best match up in the passing game. Foles just needs to look somewhere else when Harrison Smith is in the area.
As far as an offensive player the Eagles have who concerns me the most, I think it is Jay Ajayi. I know how good Ajayi can be. If he has some big runs it causes other problems for the defense as they have to focus more on stopping the run. I think Ajayi is good enough to overcome great defense with his runs at times. So if he does, and especially early in the game, I think that puts more pressure on the Vikings defense, maybe forcing them to play a 3rd linebacker over Newman more often.
Vaitai needs to play as perfect a game as he can and I still think they absolutely need to give him help. Everson Griffen will eat him alive otherwise.
This is a match up that the Vikings need to win I think. Griffen has slowed down recently, dealing with a foot injury.
In the same vein Rashod Hill needs to do a good job against Graham. I am worried about Cox as well. I think Cox may be part of the reason why the Vikings are playing Remmers at left guard. They are trying to shore up the interior blocking with that move.
LIke you I expect this to be a close game. I dunno about either defense being able to "shut down" the opposing offense, but I do expect both defenses to win more plays than the offenses will.