McCaffrey - One of the most disappointing 1st overall picks in many years.
Etienne - For a RB typically drafted in the top 2-3 rounds, he has been brutally bad.
Z White - Not drafted as high, but considering it was assumed he would be the LVR RB1, he's done basically nothing.
Olave - Yeah, he's been hurt. But, even when he's played, he's been borderline unstartable.
Harrison - Still have high expectations for him long-term, but he hasn't been a low-end WR1 in redraft leagues like expected.
Kincaid - Target hog, yeah right.
Pitts - Food me once, shame on you. Twice, shame on me.
Then there is a disturbingly long list of guys who might not have been busts, but they sure were disappointing. Mostly WR's. Hill/Waddle, Wilson/Adams, Diggs/Dell, D Smith, Pittman, Deebo, Cooper, Kirk, Ridley, D Johnson, Reed, etc.