"Healthy, working adults who received influenza vaccine reported 25 percent fewer episodes of upper respiratory illness than those who received the placebo (105 vs. 140 episodes per 100 subjects, P < 0.001), 43 percent fewer days of sick leave from work due to upper respiratory illness (70 vs. 122 days per 100 subjects, P = 0.001), and 44 percent fewer visits to physicians' offices for upper respiratory illnesses (31 vs. 55 visits per 100 subjects, P = 0.004). The study, reported in the NEJM, estimated cost savings at $46.85 per person vaccinated, and concluded that "Vaccination against influenza has substantial health-related and economic benefits for healthy, working adults.""