The Z Machine
Footballguy
Damn, I thoughti had it bad.
GLLLLLLLLL out there, boys.
GLLLLLLLLL out there, boys.
It’s probably no consolation, but technically a vaccinated person isn’t required to quarantine post exposure, unless they develop symptoms (current CDC guidelines, which didn’t change with delta…who knows if they should have) . Your exposure was barely over 15 minutes, mitigated by masks and vaccination. I don’t know the community prevalence of covid in your area, or the rapid test you used, but even if it’s pushing 10%, your likelihood of a false negative test is less than 5%. And the kid’s confirmatory test being positive is by no means guaranteed.Wife and I just rapid tested and both were negative.
My dad just called and said he's coming. Not sure what changed his mind. I'm emotional about this thing right now... thankfully they have to drive 2 hours to get here.
I am saying when someone who has been vaccinated will still shed the virus once they get covid. After that they have vax and NI. Then they won't shed.To clarify:
When you say "shed" are you referring to a vaccinated person being able to contract the virus naturally, and then shed the virus that virus and spread infection?
OR
Are you saying that when someone is vaccinated, that they are shedding virus based on the body's response to the vaccine, and infecting people, WITHOUT having contracted the virus itself?
Why don’t you share your theory with us?Africa has 6% vaccinated and has the Lowest covid numbers by far anywhere. I think there are many factors why but you tell me.
What do you mean by "shed"?I am saying when someone who has been vaccinated will still shed the virus once they get covid. After that they have vax and NI. Then they won't shed.
Thank you. The outdoor Thanksgiving worked out pretty well at a park pavilion in 50 degree weather. And the last I heard late today she's feeling better.Seems like a smart plan. Hope she is ok and everyone else stays healthy.Thanksgiving plans just changed in 1 phone call. 16-year-old granddaughter woke up sick with cough, fever, swollen lymph nodes. So we're switching from 9 of us indoors to 8 of us outdoors. Not sure how we'll transport all the food, some might get left behind, but we're still getting together after not being able to last year. It will be a cluster #### but probably one we'll enjoy and remember.
Some real coflicting strong emotions to deal with --- self-preservation vs. desire to be with family. This is the best plan my son and I could come up with.
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Give off the virus after contacting it.What do you mean by "shed"?
Thank you. When you say "shedding" you mean "spreading the virus to others".Give off the virus after contacting it.What do you mean by "shed"?
We are on the same page.Thank you. When you say "shedding" you mean "spreading the virus to others".
There are complete nutballs who belive that vaccinated people can "shed" the vaccine itself and cause medical problems in others, and they also call it "shedding".
That is why I've asked you about what you mean by shedding so many times. You mean "spreading", not what the complete nutballs mean.
"Published online 2020 Dec 22"
I think there is much newer."Published online 2020 Dec 22"
Do you have anything newer? Thanks.
So there might be something more recent with with more information on the case level in Africa and the cause(s) for it. I'm too tired to look for it tonight but I'll read it if you find it and post it.I think there is much newer.
Also, they have far fewer old people.https://www.bmj.com/content/375/bmj.n2512
Same jist. I think this is mostly because how they live, in less concentration and they had the worst viruses in the world already.
Yep 20 average compared to 43 elsewhere. Great point!Also, they have far fewer old people.
It’s similar to the mostly rural states in the US - they can keep the numbers down but when it gets into a town or village, it will rip it apart. In some remote nations there isn’t the cross over between rural and urban. In the US we have holiday gatherings where kids come back from college and other family members get together. I’d expect the rural, lower-vaxxed areas to get hit hard soon.https://www.bmj.com/content/375/bmj.n2512
Same jist. I think this is mostly because how they live, in less concentration and they had the worst viruses in the world already.
Now what? Why are you asking me?Now what?
If I posted a summary you would ask for links.Now what? Why are you asking me?
Thanks for sharing your links. I enjoy reading and learning. It was interesting. A summary would have been better, but oh well.
Svalbard has covid....It’s similar to the mostly rural states in the US - they can keep the numbers down but when it gets into a town or village, it will rip it apart. In some remote nations there isn’t the cross over between rural and urban. In the US we have holiday gatherings where kids come back from college and other family members get together. I’d expect the rural, lower-vaxxed areas to get hit hard soon.
Okay, you know Natural Immunity works against variants? Our bodies figured this stuff out long ago. We adjust.World, meet the "Nu" variant
A new "highly mutated" pending "Variant of interest" out of Africa/Botswana that is ripping through schools with a host of mutations... 30 alone to spike protein which may (or may not) suck, and possible T cell evasion (which would likely suck).
Of particular concern is POSSIBLE strong competition vs Delta. Too early to tell though.
Quotes:
“The mutation profile gives us concern, but now we need to do the work to understand the significance of this variant and what it means for the response to the pandemic.
...
"Researchers spotted B.1.1.529 in genome-sequencing data from Botswana. The variant stood out because it contains more than 30 changes to the spike protein — the SARS-CoV-2 protein that recognizes host cells and is the main target of the body’s immune responses. Many of the changes have been found in variants such as Delta and Alpha and are linked to heightened infectivity and the ability to evade infection-blocking antibodies.
But the variant’s apparent sharp rise in South Africa’s Gauteng province — home to Johannesburg — is also setting off alarm bells. Cases increased rapidly in the province in November, particularly in schools and among young people, according to Lessells. Genome sequencing and other genetic analysis from de Oliveria’s team found that the B.1.1.529 variant was responsible for all of 77 of the virus samples they analysed from Gauteng, collected between 12 and 20 November. Analysis of hundreds more samples are in the works.
The variant harbours a spike mutation that allows it to be detected by genotyping tests that deliver results much more rapidly than genome sequencing, Lessells said. Preliminary evidence from these tests suggest that B.1.1.529 is spreading much wider than Gauteng. “It gives us concern that this variant may already be circulating quite widely in the country,” Lessells said."
...
"The variant harbours a high number of mutations in regions of the spike protein that antibodies recognize, potentially dampening their potency. “Many mutations we know are problematic, but many more look like they are likely contributing to further evasion,” says Moore. There are even hints from computer modelling that B.1.1.529 could dodge immunity conferred by another component of the immune system called T cells, says Moore. Her team hopes to have its first results in two weeks."
story:
https://www.nature.com/articles/d41586-021-03552-w
discussion:
https://www.reddit.com/r/COVID19/comments/r25925/heavily_mutated_coronavirus_variant_puts/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
Scary stuff no doubt.World, meet the "Nu" variant
A new "highly mutated" pending "Variant of interest" out of Africa/Botswana that is ripping through schools with a host of mutations... 30 alone to spike protein which may (or may not) suck, and possible T cell evasion (which would likely suck).
Of particular concern is POSSIBLE strong competition vs Delta. Too early to tell though.
Quotes:
“The mutation profile gives us concern, but now we need to do the work to understand the significance of this variant and what it means for the response to the pandemic.
...
"Researchers spotted B.1.1.529 in genome-sequencing data from Botswana. The variant stood out because it contains more than 30 changes to the spike protein — the SARS-CoV-2 protein that recognizes host cells and is the main target of the body’s immune responses. Many of the changes have been found in variants such as Delta and Alpha and are linked to heightened infectivity and the ability to evade infection-blocking antibodies.
But the variant’s apparent sharp rise in South Africa’s Gauteng province — home to Johannesburg — is also setting off alarm bells. Cases increased rapidly in the province in November, particularly in schools and among young people, according to Lessells. Genome sequencing and other genetic analysis from de Oliveria’s team found that the B.1.1.529 variant was responsible for all of 77 of the virus samples they analysed from Gauteng, collected between 12 and 20 November. Analysis of hundreds more samples are in the works.
The variant harbours a spike mutation that allows it to be detected by genotyping tests that deliver results much more rapidly than genome sequencing, Lessells said. Preliminary evidence from these tests suggest that B.1.1.529 is spreading much wider than Gauteng. “It gives us concern that this variant may already be circulating quite widely in the country,” Lessells said."
...
"The variant harbours a high number of mutations in regions of the spike protein that antibodies recognize, potentially dampening their potency. “Many mutations we know are problematic, but many more look like they are likely contributing to further evasion,” says Moore. There are even hints from computer modelling that B.1.1.529 could dodge immunity conferred by another component of the immune system called T cells, says Moore. Her team hopes to have its first results in two weeks."
story:
https://www.nature.com/articles/d41586-021-03552-w
discussion:
https://www.reddit.com/r/COVID19/comments/r25925/heavily_mutated_coronavirus_variant_puts/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
Infection-Acquired immunity isn't automatic against variants... highly dependent on level/type of mutation.Okay, you know Natural Immunity works against variants? Our bodies figured this stuff out long ago. We adjust.
Thanks for posting that from wherever Matt.Infection-Acquired immunity isn't automatic against variants... highly dependent on level/type of mutation.
Over time, yes. Infection-Acquired immunity will adapt to compensate.
Assuming your infection-acquired immunity to a Delta infection automatically protects you against all strains would be incorrect as far as I understand.
Others who know more can clarify, but from my understanding there is a possibility (albeit slight) that a variant could mutate to such a degree that we would be starting at borderline ground zero WRT "herd immunity".
If that were to happen, mRNA vaccines could likely be adapted quite quickly... within weeks. Again, based on previous reading... please correct me if I'm wrong.
I doubt you still have my # but if so, feel free to call. At the cabin.Infection-Acquired immunity isn't automatic against variants... highly dependent on level/type of mutation.
Over time, yes. Infection-Acquired immunity will adapt to compensate.
Assuming your infection-acquired immunity to a Delta infection automatically protects you against all strains would be incorrect as far as I understand.
Others who know more can clarify, but from my understanding there is a possibility (albeit slight) that a variant could mutate to such a degree that we would be starting at borderline ground zero WRT "herd immunity".
If that were to happen, mRNA vaccines could likely be adapted quite quickly... within weeks. Manufacturing/production would take time. Unsure on FDA clearance but one would assume it would be quick given it's a tweak of an existing approved vaccine. Again, based on previous reading... please correct me if I'm wrong.
Those were my words not pulled from anywhere. Granted I'm about 20 beers and 15mg of THC into my evening at the in-laws in Kentucky, so my logic might get exposed as dumb AF by the morning.Thanks for posting that from wherever Matt.
Im sure I do somewhere but I'm crashing. The crew is all asleep and if I get on the phone now I'll get my ### reamed. Someday soon tho buddy :cheers:I doubt you still have my # but if so, feel free to call. At the cabin.
You tied the knot? Sry bro frigging congrats!Those were my words not pulled from anywhere. Granted I'm about 20 beers and 15mg of THC into my evening at the in-laws in Kentucky, so my logic might get exposed as dumb AF by the morning.
Noooo! I just call em in-laws. We are 18 years in. Might as wellYou tied the knot? Sry bro frigging congrats!
Two possibilities:Okay, seriously question. How does this all stop, because with 100% of the world vaxx it wouldn't stop.
The thing to remember is we are chasing a cure for a super version of the common cold. The world may be stuck with this family of coronavirus forever. It is in wild animal populations.Okay, seriously question. How does this all stop, because with 100% of the world vaxx it wouldn't stop.
IMO, a treatment/drug that turns it into a 2-3 day moderate "flu/cold" is the most likely near term "win" for us. Once that happens, we can treat it as such, which means life is pretty much lived normally.Okay, seriously question. How does this all stop, because with 100% of the world vaxx it wouldn't stop.
What events over the past 18 months have given you the idea that the FDA would respond quickly or nimbly if we needed a tweaked vaccine?Infection-Acquired immunity isn't automatic against variants... highly dependent on level/type of mutation.
Over time, yes. Infection-Acquired immunity will adapt to compensate.
Assuming your infection-acquired immunity to a Delta infection automatically protects you against all strains would be incorrect as far as I understand.
Others who know more can clarify, but from my understanding there is a possibility (albeit slight) that a variant could mutate to such a degree that we would be starting at borderline ground zero WRT "herd immunity".
If that were to happen, mRNA vaccines could likely be adapted quite quickly... within weeks. Manufacturing/production would take time. Unsure on FDA clearance but one would assume it would be quick given it's a tweak of an existing approved vaccine. Again, based on previous reading... please correct me if I'm wrong.
1) Well, you asked for our theories — not for us to post links of other people’s theoriesIf I posted a summary you would ask for links.
The chief medical adviser to the UK Health and Security Agency has warned that a newly identified Covid-19 variant in southern Africa is the “most worrying we’ve seen”, with transmission levels not recorded since the beginning of the pandemic.Good Twitter thread here:
https://twitter.com/peacockflu/status/1463176821416075279?s=21
BBC now with an article:
https://www.bbc.com/news/health-59418127
Reuters "UK Alarmed by new strain"
https://www.reuters.com/business/healthcare-pharmaceuticals/uk-flags-concern-over-newly-identified-coronavirus-variant-2021-11-25/
The thing to remember is we are chasing a cure for a super version of the common cold.
Was going to post this but you beat me to it. Just in time for the holidays!World, meet the "Nu" variant
A new "highly mutated" pending "Variant of interest" out of Africa/Botswana that is ripping through schools with a host of mutations... 30 alone to spike protein which may (or may not) suck, and possible T cell evasion (which would likely suck).
Of particular concern is POSSIBLE strong competition vs Delta. Too early to tell though.
Quotes:
“The mutation profile gives us concern, but now we need to do the work to understand the significance of this variant and what it means for the response to the pandemic.
...
"Researchers spotted B.1.1.529 in genome-sequencing data from Botswana. The variant stood out because it contains more than 30 changes to the spike protein — the SARS-CoV-2 protein that recognizes host cells and is the main target of the body’s immune responses. Many of the changes have been found in variants such as Delta and Alpha and are linked to heightened infectivity and the ability to evade infection-blocking antibodies.
But the variant’s apparent sharp rise in South Africa’s Gauteng province — home to Johannesburg — is also setting off alarm bells. Cases increased rapidly in the province in November, particularly in schools and among young people, according to Lessells. Genome sequencing and other genetic analysis from de Oliveria’s team found that the B.1.1.529 variant was responsible for all of 77 of the virus samples they analysed from Gauteng, collected between 12 and 20 November. Analysis of hundreds more samples are in the works.
The variant harbours a spike mutation that allows it to be detected by genotyping tests that deliver results much more rapidly than genome sequencing, Lessells said. Preliminary evidence from these tests suggest that B.1.1.529 is spreading much wider than Gauteng. “It gives us concern that this variant may already be circulating quite widely in the country,” Lessells said."
...
"The variant harbours a high number of mutations in regions of the spike protein that antibodies recognize, potentially dampening their potency. “Many mutations we know are problematic, but many more look like they are likely contributing to further evasion,” says Moore. There are even hints from computer modelling that B.1.1.529 could dodge immunity conferred by another component of the immune system called T cells, says Moore. Her team hopes to have its first results in two weeks."
story:
https://www.nature.com/articles/d41586-021-03552-w
discussion:
https://www.reddit.com/r/COVID19/comments/r25925/heavily_mutated_coronavirus_variant_puts/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
Turing over COVID detection and treatment to PR departments and internet conspiracists seems like a lousy idea.Willy said:As Ivan has mentioned we're going to need to burn down the FDA/CDC so we can actually get tailored vaccines and anti-virals and other treatments as they are developed and proven safe and effective
Turing over COVID detection and treatment to PR departments and internet conspiracists seems like a lousy idea.