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***OFFICIAL CYDY/Leronlimab Thread*** (6 Viewers)

chet said:
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👍🏼  
 

Everyone got a PhD in biotechnology/pharma

Watched Fear City on Netflix last night.  Quote from a soldier “we couldn’t put a sentence together, but we were watching TV and discussing RICO like we went to Harvard Law”

 
@YoDoctorYo

If you all didn’t get my Karate Kid reference, Dr. Bruce Patterson is on my show Friday July 31st. Tentative time is 9pm EST/ 6pm PST. Will be broadcasted on YouTube, Facebook and Periscope. It’s going to be mad banging!!
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chet said:
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If I go down, I followed the smart money and it didn’t work out. I’ll try again next time and the time after and after.

I said it months ago, I’m not selling until you do. I hold you zero percent accountable for my actions. 

Otis$9 or 9Otis; can we change his user handle? 

 
Jayrok said:
He's a young hip doc. Probably knows many or most of his online followers are millennials.  Or something.  :shrug:
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Gives himself Dr. Yo twitter handle.

coins #itsRANTESnotpanties twitter hashtag

Drops the Mad Banging phrase.

Comes up with crazy analogies like they are going out of business.

I'm rooting for this dude.  He's legit.

 
ILUVBEER99 said:
Gives himself Dr. Yo twitter handle.

coins #itsRANTESnotpanties twitter hashtag

Drops the Mad Banging phrase.

Comes up with crazy analogies like they are going out of business.

I'm rooting for this dude.  He's legit.
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He idolizes Dr. Patterson as well.,

 
dkp993 said:
Fear.  The CYDY talk has never recovered from its 3 day spike and subsequent fall back to the 5’s.  
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Was online checking the SP and was patting myself on the back then saw the price drop a $1 in @ twenty seconds and thought there was some kind of mistake and then mind drifted to a RICO indictment as the SP plummeted. It shook this novice investor.

 
cosjobs said:
seems mean. He's not perfect, but its hard to imagine having gotten someone who could have propelled the drug this far, this quickly. But yes, he is certainly flawed and maybe we should consider someone else for the next level. But who is available and what will they cost?
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You seem to be suggesting that Nader is one of few who could have done this with this drug. I can't buy into that. IMO, he's more than flawed. He's something of an entrepreneur who got an opportunity, did something with it, and should move on now that the company needs that next-level leadership. He does not have the skills and is less an asset and more a liability. Nice guy? Sure. Family man? Yeah. Made some mistakes? Yes. Exhibit good judgement. History suggests not. Self aware? I don't see it. 

He absolutely should not be the face of this company. We are leaving something on the table doing so. 

I'm a believer, but not because of NP. In fact, he's the reason why I consider bailing.

 
⚡DEADHEAD⚡ said:
I'm a believer, but not because of NP. In fact, he's the reason why I consider bailing.
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Same here. Every time I’ve thought about unloading, NP is at the forefront of the thought process. As a shareholder I have no issue offering a big package with big incentives for a seasoned pharma exec to take this company to the next level. NP def helped get it from penny stock to speculative growth... Company now needs a seasoned exec to go from speculative growth to medium sized pharma. 

 
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.

 
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Don Hutson said:
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.
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I see lots of negative comments. The two previous posts by Deadhead & I are far from ringing endorsements of the leadership of the company.

 
Don Hutson said:
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.
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I'm certain that everyone knows by now that there are warts on the company.  Most post are essentially "we believe the science and trust the scientists involved" and "I wish the CEO was not so much the way he is..." or wished he was more of a professional in terms of being the spokesman for the company.  

Agree that attacking posters who provide negative comments is not helpful to the thread.  At the same time, it can be expected that posters will comment to defend the company/research as well, where applicable.  Nothing wrong with discussions like that.  Some, it seems, have devolved and looked to get personal.  And that's too bad.  

Also agree that many of us have seen excellent gains already in the stock.  

I do feel like the longer the news takes, day by day, the SP will leak south and wouldn't be surprised at all if we see it below 4 next week if all is quiet.  People are antsy.  Some are holding regardless, others are likely looking to secure some profits as it drops and look to buy back at certain points. I'm the latter.  But I will hold a small position regardless of what the Covid results reveal.  If it falls to a certain point, I look to load up and hopefully see a rise with anticipation of uplisting and HIV approval.  My 2 cents.  

 
Jayrok said:
I do feel like the longer the news takes, day by day, the SP will leak south and wouldn't be surprised at all if we see it below 4 next week if all is quiet.  
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Completely self-inflicted wound, and a perfect example of the CEO bashing/inexperience we discuss daily in here.

 
Discussion from Dr. Mobeen on a recently published research paper: Covid-19 severity correlates with airway epithelium-immune cell interactions identified by single cell analysis

The lecture isn't about a potential therapeutic (including Leronlimab).  He white boards the basics of the study and what they found.  It's very interesting.   

Link to study From Germany

Abstract

To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In patients with COVID-19, epithelial cells showed an average three-fold increase in expression of the SARS-CoV-2 entry receptor ACE2, which correlated with interferon signals by immune cells. Compared to moderate cases, critical cases exhibited stronger interactions between epithelial and immune cells, as indicated by ligand–receptor expression profiles, and activated immune cells, including inflammatory macrophages expressing CCL2, CCL3, CCL20, CXCL1, CXCL3, CXCL10, IL8, IL1B and TNF. The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. Our data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19.
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Because binding of CCL2 or CCL3 to CCR1, CCR2 or CCR5 can induce monocyte recruitment into the lung parenchyma with subsequent differentiation into inflammatory macrophages and consecutive recruitment and activation of additional immune cells and epithelial damage, CCR1, CCR2 and CCR5 might represent promising anti-inflammatory targets in COVID-19. Targeting the CCR2/CCL2 axis has been introduced in HIV and other viral infections53. However, we did not observe CCR2 expression in the respiratory tract of patients with COVID-19 (presumably because of its rapid downregulation in monocytes as they exit the bloodstream and enter tissues; Extended Data Fig. 7), leaving CCR1 and/or CCR5 as potential therapeutic targets.
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Near the end of the discussion when he's taking questions, he does mention Leronlimab as the one CCR5 blocker that he knows of.  The study seems to indicate that early on in treatment doctors would have a window of 6ish hours to use steroids (I suppose until the immune system goes into over-drive causing the Cytokine storm) to prevent the patient from degrading into more severe cases.  He said that they're also saying CCR1 and CCR5 disrupting medications can also be used and said "the one that I know is Leronlimab."  

 
This paper was published in Nature on 26 June 2020.  I wonder when it was written... as Dr. Patterson's paper is still in peer review.  This study shows immune cell interactions with Covid severity as identified by single-cell analysis.  Dr. Patterson's paper also touches on this area of how the immune system responds and how targeting CCR5 receptors with medication can quieten down the immune response.  But his goes the next step in showing how a therapeutic like LL can target these receptors and prevent the patient from degrading into more severe cases.  It has shown in emergency INDs that it has enabled patients to come off life support.  

It seems BP's paper would go right along with this German study as sort of a sequel of studies.  This study shows what's happening and what can be targeted for therapy.  Bruce's study goes further and shows how LL (or another CCR5 antagonist) can target the receptor and help the patient. 

His study would then seem to compliment the German study.  Is it possible that his study is now closer in the queue to be published in Nature?   :shrug:

 
Don Hutson said:
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.
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Like every person in this thread has posted something negative about the company and/or CEO. What are you talking about. 

 
Don Hutson said:
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.
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I think most people who are invested get annoyed when some just calls it a pump and dump.  While that may be true, they can't possibly know that and the data and actions of the company suggest otherwise.  At least to me.

From what I have seen, most are very willing to listen to the counter arguments and only a few people really care about "motives".  It just doesn't matter what someone's motive is.  People should do their own due diligence and if they believe in the stock, then they buy or hold, and if they don't short it or sell it.  

And it sucks when it gets personal because as you say, getting too emotionally involved is bad for stonks.

 
JAA said:
Good news. Discussion on needs for therapeutics:  https://abcn.ws/30NF3hd
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White house chief of staff:  "We're hopeful that with some of the breakthrough technology on therapeutics that we'll be able to announce some new therapies in the coming days."

"And I'm hopeful that in the next couple of days that we'll have some very good news on the therapeutic and vaccine fronts..."   

Announce some NEW therapies in the coming days.  No talk of Remdesivir or Chloriquin there.  Nice. 

 
Don Hutson said:
It seems to upset some people when anything negative is said about CYDY.  Do we really want this to be a thread where all we do is cheerlead and ignore the many warts of the company?  If you find yourself seething and attacking people because of anti-CYDY sentiments, then you've probably emotionally invested yourself too much into the stock.  It is never smart to do that.  A smart investor detaches themselves as much as possible.  We've all made a lot of money on CYDY.  Let's not lose those gains.  For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.  I do plan on buying it back when the S/C review comes up.
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Get over yourself. We’re all adults and while the only person I really have disdain for is the guy who came in as if he was here to save us and said he wanted to short the stock in his first post, your post is annoying. It’s a thread where we are supposed to post what we are thinking. We don’t need to be saved. Even with the drop from $10, I’m still up tens of thousands.

You we’re being a #### to another poster and he was being a #### back. The guy you got into it with is up a ton as well and I agree with him that his daughter didn’t say the same thing as shorty. That said I don’t think most clinical trial data gets unpacked in less than a week and we actually did get an early pick at some numbers that are easier to get. So even I don’t fully agree with her but you acted like a #### even though you’re here to tell us how to act. Amazing that you get into a silly message board scuffle over a stock you don’t own. Wee bit hypocritical in my mind.

 
Caesar said:
I think most people who are invested get annoyed when some just calls it a pump and dump.  While that may be true, they can't possibly know that and the data and actions of the company suggest otherwise.  At least to me.

From what I have seen, most are very willing to listen to the counter arguments and only a few people really care about "motives".  It just doesn't matter what someone's motive is.  People should do their own due diligence and if they believe in the stock, then they buy or hold, and if they don't short it or sell it.  

And it sucks when it gets personal because as you say, getting too emotionally involved is bad for stonks.
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Totally agree. Acting as if none of us have had doubts or complained about how things were done is silly. It’s annoying when people tell you to not be emotional or that you’re ignoring things or that it’s a scam especially when it’s clear that they have ulterior motives. Someone who’s praised for being objective is funny when he’s clearly not. Objective doesn’t say pump and dump for a company whose drug is actually in clinical trials. That’s not boiler room. Whether it pans out or not is a legit comment, saying you wanted to be short and quoting people clearly shorting the stock isn’t objective.

 
Jayrok said:
Meadows says White House is 'hopeful' it can announce new coronavirus therapies 'in the coming days
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I know it’s pie in the sky but it would be amazing if the WH has their eye on LL trials. Remdesivir has bad side effects and just helps a little and it got pushed through in part due to connections. Here’s to hoping for really good trial results that can get us nudged forward because as I posted earlier in this thread, I don’t think there is anything more important to the Trump campaign than CV therapeutics and vaccines. On a humanitarian level, I’d be fine with 4 more years of Trump if we could truly get past CV with therapeutics that keep deaths and long term problems way down and a vaccine to get us back to normal. It would suck for the stock if it’s something else, but I want back to normal bad.

 
stbugs said:
I know it’s pie in the sky but it would be amazing if the WH has their eye on LL trials. Remdesivir has bad side effects and just helps a little and it got pushed through in part due to connections. Here’s to hoping for really good trial results that can get us nudged forward because as I posted earlier in this thread, I don’t think there is anything more important to the Trump campaign than CV therapeutics and vaccines. On a humanitarian level, I’d be fine with 4 more years of Trump if we could truly get past CV with therapeutics that keep deaths and long term problems way down and a vaccine to get us back to normal. It would suck for the stock if it’s something else, but I want back to normal bad.
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Part of me thinks cydy doesn’t have the money to line trump’s pockets in order to get him to promote ‘us’ but he’s so far behind in the polls it may actually be a possibility. 

 
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stbugs said:
I know it’s pie in the sky but it would be amazing if the WH has their eye on LL trials. Remdesivir has bad side effects and just helps a little and it got pushed through in part due to connections. Here’s to hoping for really good trial results that can get us nudged forward because as I posted earlier in this thread, I don’t think there is anything more important to the Trump campaign than CV therapeutics and vaccines. On a humanitarian level, I’d be fine with 4 more years of Trump if we could truly get past CV with therapeutics that keep deaths and long term problems way down and a vaccine to get us back to normal. It would suck for the stock if it’s something else, but I want back to normal bad.
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He said therapeutics (plural) so I imagine there are a few candidates that may get approval for covid treatment.  LL does not have to be the only winner here.  Just get approval and the SP will react.  Then show you're the best of the bunch... and get uplisted... then get HIV BLA approval... now we're talking.  

But I'd be happy to just get approval so we can restart that journey north.  And agree with you, I want back to normal as well.  

 
Capella said:
Part of me thinks cydy doesn’t have the money to line trump’s pockets in order to get him to promote ‘us’ but he’s so far behind in the polls it may actually be a possibility. 
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That’s what I think. Way back when before the reopening hit the fan, Gilead had the money. At this point the motive is solely to win re-election. Can’t line his pockets without the presidency. 

 
I’d love Trump to buy 10mm shares :lmao:

ive found a drug so good I’ve put $50mm of my own money into. Fast track approvals this week!

On a serious note, OAN has given some coverage to LL, and we know this guy watches them, so who knows... Wouldn’t bank on it, but we need results on severe and M2M.

 
Capella said:
Part of me thinks cydy doesn’t have the money to line trump’s pockets in order to get him to promote ‘us’ but he’s so far behind in the polls it may actually be a possibility. 
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stbugs said:
That’s what I think. Way back when before the reopening hit the fan, Gilead had the money. At this point the motive is solely to win re-election. Can’t line his pockets without the presidency. 
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Don't need money to line his pockets, a beaten down stock price so his cronies can get in cheap works just as well. 

 
Aaron Rudnicki said:
Right. While getting mad at others for saying similar things. Was odd and seemed to derail the thread a bit. 
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Cav doesn't think Wyatt is being honest.

Cav's daughter gets compared to someone being dishonest. 

Cav gets pissed off because his daughter is as unbiased and informed as a person as can be. 

Basically Cav is being a great dad and protecting his daughter's honor. Seems understandable.

#notselling

 
Don Hutson said:
For full disclosure, I sold 100% of my stock at 9:31am on Tuesday morning.
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Well...'full disclosure' would have been telling us that on Tuesday. Instead, you've posted negative comments about CYDY (which you have every right to do) without telling us you were not long the stock any more (which seems south of excellent posting). While no one owes us detailed accounts of their trades, this stock and thread are a little different.

 
Not that this means anything, but I talked to my SIL last night about CYDY. She is a financial advisor by trade and quite successful at it. Her and my brothers portfolio is pretty healthy from what I understand.

Anyway, we are just sitting around chatting and I just tell her where I heard about it, the history, etc. We move on to other topics, just shooting the bull with my brother. All the while she is looking at her phone, searching for stuff, whatever.

After about 15 minutes or so, she looks at my brother and says: “I think we’ll be in on this.”

We talked a bit about the CEO, and her words were something to the effect of: “He wouldn’t be the first bumbling CEO for an up and coming company.”

She didn’t seem concerned.

 
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