I am trying to understand today's PR and calculate some p-values based on the numbers. Placebo had 28 participants and 11 SAEs for a success rate of 17/28. Drug had 56 participants and 8 SAEs for a success rate of 48/56.
Here are the
inputs and result from a two proportion hypothesis test. It returns a p-value of ~0.0078 which is very significant. However, this doesn't tell the entire tale because some patients had
more than one SAE so the total number of placebo patients who had an SAE was 6/28 and total drug patients with an SAE was 5/56.
I don't know how to adjust for the above--anyone have a suggestion. Anyone have a suggestion?