Terminalxylem
Footballguy
Since it appears I’m not communicating well, let me restate:I counsel patients regarding diet and exercise, and reassure them when they become frustrated at the difficulty losing weight. I emphasize they shouldn't let perfect be enemy of the good, and any dietary improvement/activity increase/weight loss is better than none.
Interesting. That's quite a bit different from "unfortunately, diet and exercise seldom succeed in real world conditions."
1. Diet (most important) and exercise are the cornerstones of weight loss. Anyone who is overweight or obese should earnestly try to improve both. Any incremental improvement is better than no change in obesity-promoting behaviors.
2. Population data show us only a small percentage of people can maintain long term weight loss using behavioral modification alone, probably in the neighborhood of 10%, or less. The reasons for this level of failure aren’t entirely clear, but may partially due to adaptations that occur in obese people’s bodies in response to weight loss. This article offers some explanations.
3. Drugs like Wegovy (semaglutide) and Zepbound (tirzepatide) are far and away the most potent pharmacologic interventions available as adjuncts for weight loss. The latter is comparable in efficacy to bariatric surgery.
4. If someone fails at behavioral modification, the risks of unmitigated obesity are high.
5. Based on known pre-clinical and post-marketing data, semaglutide and tirzepatide appear to be safe. Drugs like semaglutide (exenatide) have been used in diabetics for almost two decades, so even long term use hasn’t proven a problem.
6. Every drug has potential for adverse effects, but there’s no good reason to believe weight loss drugs will prove more harmful than other chronic medications. More importantly, it’s highly improbable the likelihood of serious AEs exceeds the risk of uncontrolled obesity.
7. Most arguments against weight loss drugs don’t rationally consider points 2-6, instead viewing failed behavioral modification as laziness/lack of willpower, or placing undue emphasis on fears of the unknown, and unsubstantiated anecdotes of possible AEs.
8. While legal + cultural changes are certainly needed to stem the tide of obesity, any such change requires political will, and years-decades to take effect. In the meantime, we should use all available tools to treat obesity, including medications.
The easiest way to fight overweight/obesity is never gaining weight in the first place. It helps to have a culture that isn't centered about massive amounts of unhealthy food and beverage.With few exceptions, obesity is a problem in much of the developed world.Sustained weight loss is really hard for Americans but not for other cultures??
Yeah, not buying it.
Better diet, more exercise. Americans are lazy and fat.
Yeah, the idea of lazy American's as it pertains to obesity is really lazy humans. We are basically the top major world power but just about everybody on the planet is overweight (by BMI) save several African nations and the far East.
Most Obese Countries 2024
worldpopulationreview.com
Thanks. Why do most people think US is 36% and Japan, a very developed country, is 4%?
Maybe you missed this.This goes back to my water is wet comment. The way food is made/sold/marketed is different. We’re old enough that we remember the microwave being introduced. Remember the hungry man ads? We went from cooking with fresh ingredients, for the most part, to cooking prepacked crap laden with preservatives, sugar, salt, all the wrong oils and HFCS.this is not something "everyone can do." In fact, barely anyone can do it
Do you have thoughts on:
1. Why it seems that 50 years ago, lots of people were able to not be obese?
2. Why today in countries like Japan, 96% of the population is able not to be obese?
Take popcorn. Extra buttery microwave popcorn. Really not good for you. Loaded with trans fats and other chemicals. If you Cook the popcorn your self you control what goes in it. That’s an easy 3-4 hundred calorie difference and no chemicals/transfats. Hell, you could cook it in bacon fat and it will be healthier for you.
Occam’s razor.
Thanks. I saw your post. Was wondering if @AAABatteries had thoughts. And others of course too.
I find the "hardly anyone can do it" fascinating when somehow someway 96% of Japanese people do it.
Once you gain it, the body fights attempts at weight loss, as starvation is generally undesirable for short-term survival.
All that said, it would be interesting to see how frequently obese Japanese people are able to maintain weight loss via behavioral modification, vs. Americans.