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Interesting. When my wife tested positive it lit up like right away and very dark.
I hope that you feel well soon GB.
Covid Nasal Vaccines Get A Boost
Facts, data, and analytics about biomedical matters.erictopol.substack.com
erictopol.substack.com
It looks like the last several attention-getting variants haven't really done much -- at least not in terms of increasing infirmity and affecting society. All varieties of COVID have spread so well, it doesn't seem like "it spreads more" has as much of an impact as one might expect any more. They all "spread more". It's always "spreading more".
Like the part in red. All COVID has always has "very high affinity" to the ACE2 receptor. So far as I understand it ... that's not a new feature of the virus.
Yes, that is true, but if my understanding is correct, there have been varying degrees of "stickiness" (my word) amongst the different variants. And this one is towards the "stickier" end of the scale.
194 To corroborate these findings, we also evaluated the susceptibility of both BA.2.86 pseudoviruses
195 to neutralization by the dimeric human-ACE2-Fc protein, in comparison to BA.2, XBB.1.5, and
196 EG.5.1. In agreement with the SPR data, both versions of BA.2.86 were >2-fold more sensitive
197 to ACE2 inhibition than XBB.1.5 and EG.5.1, as determined by their IC50 values (Figure 4b). A
198 potential explanation for this heightened affinity may reside in the intrinsic charge properties of
199 the two interacting molecules. The region of human ACE2 targeted by the RBD is negatively
charged, while the Omicron RBD itself is positively charged32 200 . The higher receptor binding
201 affinity of the BA.2.86 spike might be attributed to the additional positive charges associated with
202 mutations V445H, N460K, N481K and A484K (Figure 4c). Only the N460K mutation is shared
203 with the spikes from XBB.1.5 and EG.5.1.253 Another scientific implication of our results is that the RBD of BA.2.86 is likely to be more
254 exposed than the RBD of XBB.1.5 or EG.5.1. This conclusion is inferred from the above
255 observation that the new variant is more sensitive than XBB.1.5 or EG.5.1 to neutralization by
256 class 1 and 4/1 mAbs, which target the “inner face” of RBD only when this domain is in the “up”
257 position. Since receptor binding also occurs when the RBD is “up”, this conclusion is in line
258 with the finding that the spike of BA.2.86 has a >2-fold higher affinity for the viral receptor
259 compared to the spike of XBB.1.5 or EG.5.1 (Figures 4a and 4b). In fact, BA.2.86 spike has
260 one of the highest receptor affinities we have measured, together with the spikes of some of the
viruses in the BA.2.75 sublineage
261 but the KD is undoubtedly determined by additional properties
262 including the electrostatic charge of the RBD (Figures 4c).
What?? You don't have random people just coming up and talking to you about the negative impacts of the vaccine?
Of course not. But they do tell me about their small weiners which I think is odd. https://www.totalwine.com/dynamic/490x/media/sys_master/twmmedia/hec/h39/26971202486302.pngWhat?? You don't have random people just coming up and talking to you about the negative impacts of the vaccine?
I know a little German ...Of course not. But they do tell me about their small weiners which I think is odd. https://www.totalwine.com/dynamic/490x/media/sys_master/twmmedia/hec/h39/26971202486302.pngWhat?? You don't have random people just coming up and talking to you about the negative impacts of the vaccine?
Saw this when you posted it. Sounds like it could also be a big breakthrough for thrombosis in general as well, regardless of cause.Protein interaction causing rare but deadly vaccine-related clotting found - University of Birmingham
Discovery means potential protective treatments could be developed to block thrombosis from developing following vaccination.www.birmingham.ac.uk
I don't know about the fall 2023 (current) boosters, but I know that the 2021 Moderna shots were triple the dosage of the Pfizer ones. Some researchers felt like this caused more reports of side effects from the Moderna vaccine than the others.
I had no side effects for any of the covid shots up to these 2 shots.
My lady just got hers on Monday and she was down for 24 hours with headaches, chills and just feeling crappy.
Is that waning immunity we’re seeing in the most recent quarter?
I think you also have to consider the cumulative immunity due to vaccination/prior infection. Restated, I don’t think the decrease in excess deaths is purely a function of a less deadly virus.
The chart isn't from zero hedge. That's why I just included the picture.
Bout that time again
Undiagnosed pneumonia outbreak in China puts pressure on pediatric hospitals, prompts questions
Media reports describe overwhelmed children's hospitals in multiple locations in China.www.cidrap.umn.edu
JUST IN—A new "mystery pneumonia" is tearing through China's schools. Hospitals are reportedly overwhelmed in Beijing and Liaoning with sick children and many classes are already cancelled.
Symptoms include inflammation in the lungs and a high fever but without a cough or other symptoms that normally come with respiratory illnesses.
The alert came Tuesday via ProMed, a global surveillance system that monitors outbreaks, and it was a ProMed in December of 2019 that first alerted the world to a virus outbreak in China that would later be called COVID.
Hey, pal don’t call me buddy!Bout that time again
Undiagnosed pneumonia outbreak in China puts pressure on pediatric hospitals, prompts questions
Media reports describe overwhelmed children's hospitals in multiple locations in China.
JUST IN—A new "mystery pneumonia" is tearing through China's schools. Hospitals are reportedly overwhelmed in Beijing and Liaoning with sick children and many classes are already cancelled.
Symptoms include inflammation in the lungs and a high fever but without a cough or other symptoms that normally come with respiratory illnesses.
The alert came Tuesday via ProMed, a global surveillance system that monitors outbreaks, and it was a ProMed in December of 2019 that first alerted the world to a virus outbreak in China that would later be called COVID.
Hey, screw you buddy and your thread!
Might be here.Bout that time again
Undiagnosed pneumonia outbreak in China puts pressure on pediatric hospitals, prompts questions
Media reports describe overwhelmed children's hospitals in multiple locations in China.
JUST IN—A new "mystery pneumonia" is tearing through China's schools. Hospitals are reportedly overwhelmed in Beijing and Liaoning with sick children and many classes are already cancelled.
Symptoms include inflammation in the lungs and a high fever but without a cough or other symptoms that normally come with respiratory illnesses.
The alert came Tuesday via ProMed, a global surveillance system that monitors outbreaks, and it was a ProMed in December of 2019 that first alerted the world to a virus outbreak in China that would later be called COVID.
Pfft. Do you know how many people are trampled to death by hippos each year?Bout that time again
Undiagnosed pneumonia outbreak in China puts pressure on pediatric hospitals, prompts questions
Media reports describe overwhelmed children's hospitals in multiple locations in China.
JUST IN—A new "mystery pneumonia" is tearing through China's schools. Hospitals are reportedly overwhelmed in Beijing and Liaoning with sick children and many classes are already cancelled.
Symptoms include inflammation in the lungs and a high fever but without a cough or other symptoms that normally come with respiratory illnesses.
The alert came Tuesday via ProMed, a global surveillance system that monitors outbreaks, and it was a ProMed in December of 2019 that first alerted the world to a virus outbreak in China that would later be called COVID.
www.thesun.co.uk
China brings back masks & social distancing over mystery outbreak
CHINA has brought back masks and social distancing in a chilling echo of lockdown as they battle a mystery pneumonia outbreak four years on from Covid. Alarming footage has emerged of mask-wearing …
www.cdc.gov
