Multiple Monitor setup
Curious if anyone is playing this on multiple monitors and what you're finding is the best solution for the inadequacies of the game. I'm playing it at 6048x1200 including the bezel correction I have set. I'll share my setup in case it helps anyone else.
HUD:
The HUD was messed up, showing on the left display. I found a pair of fixes for it and went with Hayden's fix, version 4a since it doesn't require installing additional software that the second person's fix did. You basically launch the fix before you start Skyrim and click "Inject Patch", then start up Skyrim and it moves the display back to the middle. A lot of the time the lockpick screen ends up a little high on the screen, but nothing that hinders picking a lock.
If you use M to open the map it's good, but if you get at it otherwise you have to do an extra button press to temporarily disable the fix or the icons show up in the wrong locations.
Only real issue I've seen is the floating icons like above a person for a quest, lag behind them when they move.
Oh, and on wide screen, the cursor moves really fast in the map, making it tough to select an icon. That's just widescreen I think, not the HUD-fix I'm using. Disabling the mouse acceleration in the prefs files helped, though it still moves pretty quick.
Frames per second:
Was flying on single screen, soon as I extended my display and set up my prefs file to use it, performance dropped to around 1 frame per second. Turns out it was the anti-aliasing that was the problem. Soon as I turned it off in the setup, I was getting in the 25-30 range in busy areas and much more in a dungeon or indoors, which is very playable. (The console no longer displays FPS rate, you instead need to run a program like FRAPS to display it for you.)
I did notice the opening movie with the Bethesda Logo started lagging at the end of it when I went widescreen, so I have to sit and wait an extra 30 seconds to a minute before I can choose to load a game. I came across a crash fix of changing your sound card's output settings which I tried and I believe it fixed that issue. Though I then later went in and renamed that movie so it doesn't show at all, now it takes me straight to the Continue game screen.
I also shut down vsync which I think probably helped the framerate a little, and I haven't noticed the kind of graphics glitches it is there to fix.
4 GB mod
I grabbed the mod off the Nexus that has an executable that lets the game use 4 GB of RAM instead of the 2 it will use by default. I have had a pair of crashes that behaved differently since I went to it, but nothing occurring with any more frequency than the normal amount of crashes you expect from a Bethesda game, so sticking with it.
Xbox 360 controller on the PC
While I like aiming with the mouse, I really prefer the range of movement of a controller. So I picked up a wired controller which is plug and play with Windows 7. You cannot just plug a wireless 360 controller into Windows 7 via the recharge USB cable, it won't do anything other than charge it. Have to have a wired one, or get the wireless adapter for it.
So after I got the 360 controller then I picked up a program from the Nexus to allow you to remap the buttons on the controller. Not just remap, but it lets you add new ones including dual button presses. For example, I got rid of that menu where you choose to go to inventory, magic, map, or skills entirely, and instead I do LB + A/B/X/Y to jump straight to those menus same as the keyboard's M, I, P, etc, do. I set up quicksave to be LB+start, since there isn't a quicksave on the normal Xbox controller scheme.
One problem is if you modify some of the files it modifies, then the hotkeys don't work quite right. They will switch to a weapon, but you can't save a setup that has a weapon in each hand. Eventually someone will come out with a better set of hot keys that'll let you do full sets of armor, equipped weapons/spells, etc, so I'll just live with it for now. When I need to switch I pull up favorites and set the items manually there.
Overall it is pretty awesome on the three monitors. The peripheral vision gets stretched and zoomed in a bit, same as in Oblivion, but it's still worth it. It actually is something I take advantage of if I am trying to tell if that silhouette in the distance is a creature or a tree stump, just turn so it's in the most enlarged part of the peripheral and it's like looking at it through great binoculars.
Only real major bug I hit has been around fast traveling. A few times any time I tried to fast travel to a given location it would crash to desktop. I searched on that one and it sounds like others have hit it, and a fix is to just fast travel to somewhere closer first, and then fast travel from there, and sure enough it has fixed it the handful of times I've hit it.