I think week 5 is going to be very interesting. I hear a lot of people with bye problems that week saying they're not worried because it's early and not that many people get eliminated that week. The problem with that logic is week 5 is not as early as it seems. By the time we get there 45% of the entries will already have been eliminated and another 16% of the remaining will be out that week. I predict that a lot of teams that are among the points leaders through week 4 but have 4-5 key players out that week will be among the gonners.
Really depends on how "key" they guys are to your success, and if you have appropriate measures in place to cover their absence. 84% of remaining teams will still advance (still making it a relatively easy week, with one of the lower cut scores of the year assuming typical scoring), so you really have to have a bad week to get cut. Given that guys like Rodgers, Grant, Jennings, and the GB D are so popular, a lot of teams will be down that week for that reason anyway. I've got Rodgers, Grant, NO Def, V. Jackson, and Meachem off that week. It is in fact my biggest bye week of the year. Jackson and Meachem are the only paired positional byes for the week, and I still have 7 other WR's still going, including R. White and Ochocinco. Aside from only having Leftwich as a backup at QB, I feel pretty good about my survival chances for week 5 right now. I will also have over 1/3 of my team byes (including most of my high $ players) over at that point, so I like how that bodes for future weeks also.