I'm definitely worried about the start time. I also picked up the SF defense, and I could see that possibly affecting the DST more than the SF offense. Plus they last played on Monday night, making the turnaround to the 1 PM game even shorter. And they were certainly emotionally high against a division opponent, while nobody gets emotionally high against the Jags. (Whose nickname is synonymous with Just A (bunch of) Guys).
The biggest argument in favor of Wilson this week is he should be the lead RB in a Shanahan offense. That player (whoever it happens to be most weeks, and it doesn't seem to matter much who the player is) usually does quite well. So my biggest concern would be the role for Sermon but also Deebo Samuel. Wilson was a very effective blocker for Samuel last week, and it could happen again this week.